Position Summary

We are seeking a Senior Scientist to join our Analytical Sciences (AS) team. You have strong expertise in immuno-oncology and will be focused on focus on the development of fit-for-purpose CMC assays using flow cytometry and cell-based immunoassays, to characterize engineered TCR-T cell drug substance and drug product. This role is based in Santa Monica, CA and reports directly to the Director, Analytical Sciences.

Responsibilities

Develop analytical assays for characterizing T-cell therapy drug substance and drug products using flow cytometers and other immunoassays.
Author assay development and qualification reports with solid datasets to evaluate assay characteristics.
Perform analytical assays to provide insights for process and product.
Drive assay life cycle, including assay optimization, transfer, and qualification.
Work with Tech Operations cross-functional teams to draft study protocols, change controls and technical reports.
Author and review relevant CMC sections for regulatory submissions.
Lead projects and represent bioassay function and communicate progress or issues in CMC sub-team meetings.
Perform routine assays as a QC personnel for drug product release and characterization!

Education and Experience

7+ years with BS/BA, 5+ years with MS/MA or 2+ years with PhD in Immunology, Oncology, Cell Biology, or related field
1+ years of management experience
In-depth knowledge in immunology and cell therapy with hands-on experience working with T cells.
Hands-on experience in implementing assays and analyzing data using multi-color flow cytometry (+10 colors).
First-hand experience in different cell-based assays (e.g., Live imaging, ELISA, or MSD).
Prior work experience in a regulated environment (GLP, GMP or QC).
Technical-driven, data analysis skills and record keeping abilities.
Excellent verbal, written for scientific projects.

When we put unexpected teams in the same room, we fuel bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

The annual base salary for this position ranges from $105,875 to $158,813. However, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles) or to receive a retirement contribution (hourly roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an "at-will position" and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

Date Posted

29-Sep-2024

Closing Date

28-Nov-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.